Journal article
A public human population of TRAV26 type II natural killer T cells recognises CD1d in a lipid-independent manner
Kean Chan Yew Poa, Christopher M Harpur, Tan-Yun Cheng, Elena Batleska, Catriona V Nguyen-Robertson, Rajesh Lamichhane, Alison A White, Geovane Marques-Ferreira, Caroline Soliman, Scott JJ Reddiex, Christopher Menne, Adam P Uldrich, D Branch Moody, Jamie Rossjohn, Dale I Godfrey, Daniel G Pellicci, Jérôme Le Nours, Catarina F Almeida
Nature Communications | Springer Science and Business Media LLC | Published : 2026
Open access
Abstract
Abstract Most studies of CD1d-restricted natural killer T cells (NKT) have focused on type I TRAV10-TRAJ18 + NKT cells that recognise the glycolipid α-GalCer. Our understanding of type II NKT cells, their T cell receptor (TCR) gene usage, and their ligand specificity and diversity remains unclear. Here, using CD1d tetramers carrying diverse endogenous lipids (CD1d-endo), we identified public human TRAV26 + type II NKT TCRs present in all examined individuals, with many expressing a conserved TRAV26-2-TRAJ48 TCRα cha..
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Grants
Awarded by Department of Health | National Health and Medical Research Council